Panel from Fantastic Four (1961 series) #51 (June 1966), script by Stan Lee, pencils by Jack Kirby, inks by Joe Sinnott, letters by Artie Simek
Also, technically that's not Ben Grimm, since this is FF #51, which, if it were an episode of Friends, would be titled "The One Where That Guy Switches Bodies with The Thing." Also, if I recall, the one where Johnny Storm and Dorrie Evans were on a break. "We were on a break!" Johnny yelled, several times.